Bioscience for an integrated understanding of health

Improving animal and human health and wellbeing across the lifecourse.

*CASE: These are CASE DTP studentships. As part of the programme, you will be required to undertake a placement with the CASE partner for a minimum of 3 months.

*AP: These are Standard DTP studentships with an associate partner where you will be required to spend time with each of the partners. You will be asked to apply to one of the partners (as listed in the ‘Host Institution’ column), but this is just for administration purposes.  You will then be registered for your postgraduate studies at one of the partner universities of the lead supervisors.  Your registered university will be confirmed by the DTP following the interview stage of the selection process.

*JD: This project in collaboration with the University of Bristol and the University of the West of England (UWE) is subject to a joint degree award. Successful applicants will be registered at both these institutions, and graduates will be awarded a joint degree from these two institutions upon successful completion of the PhD programme.

 

PROJECT TITLE MAIN / ROTHAMSTED / LEAD SUPERVISOR HOST INSTITUTION KEYWORDS
Aging before birth: identifying prenatal influences of lifestyle on telomeres and the epigenetic clock Prof Rosalind John Cardiff University Fetal programming, Telomeres, Epigenetic clock, Maternal diet and nutrition, Healthy aging
Attributing the source of antimicrobial resistant diarrheal pathogens in African children Prof Samuel Sheppard University of Bath Enteric bacteria, One Health, Host adaptation, Source attribution, Antimicrobial resistance
Autophagy control of human neuroinflammatory signalling pathways *AP *JD Prof Jon Lane / Dr Lucy Crompton University of Bristol (apply through here) / University of the West of England Neuroinflammation, autophagy, glia, astrocytes, microglia
Building molecular transport machines regulated by autoinhibition and ligand-induced activation Dr Mark P Dodding University of Bristol Biodesign, Microtubule Motor, Kinesin, Cell Biology, Synthetic Biology
Developing microbiological ammunition for robust decolonization of antibiotic resistant bacteria Dr Ben Raymond University of Exeter (Penryn) Bacteriophage, antimicrobial resistance, AMR, antiobiotic resistance, evolution
HNRNPD: a master regulator of microRNAs in response to ischemic stress? Prof Lorna Harries University of Exeter (Streatham/St Luke’s) MicroRNA, HNRNPD, genomics, cell biology, cell identity
How do untranslated regions of cannabinoid receptor type 1 mRNA determine receptor subcellular localisation and function Prof Jeremy Henley University of Bristol mRNA trafficking and local translation, mRNA untranslated region (UTR), endocannabinoid system (ECS), Type 1 Cannabinoid receptor, Neuroscience
Investigating the molecular and synaptic mechanisms which underlie the sustained antidepressant effects of NMDA receptor antagonists *CASE Prof Emma Robinson University of Bristol Rapid-acting antidepressants, animal behaviour, electrophysiology, molecular biology, affective neuroscience
Mechanism of Linoleic Acid protection against SARS-CoV-2 viral replication in human cells Prof Paul Verkade University of Bristol Coronavirus, ultrastructural studies, correlative light and electron microscopy, cryo electron tomography, membrane remodelling
Non-genetic paternal effects on offspring reproduction and health: mechanisms and evolutionary consequences in a bird model system Dr Barbara Tschirren University of Exeter (Penryn) Developmental Origins of Health, Epigenetics, Reproductive Health and Bird Behaviour, Fertility and Sustainable Animal Breeding, Mechanisms of Evolutionary Change
Pharmacophylogenomics: Developing phylogenies as predictive tools in drug discovery Prof Davide Pisani University of Bristol Drug discovery, Phylogenetics, Bayesian statistics, Genomics, molecular evolution
Probing the molecular activation of complement component C5 using a novel antibody toolbox Prof Jean van den Elsen University of Bath Innate immunity, Complement, Inflammation, Protein structure
Run, eat, sleep, repeat: Hypothalamic integration of homeostatic and circadian signals Prof Hugh Piggins University of Bristol Exercise, feeding, melanocortins, circadian, sleep
Tackling antibiotic resistance through blocking of signalling pathways Dr Susanne Gebhard University of Bath Microbiology, antibiotic resistance, signal transduction, drug development, molecular biology
Understanding GPCR signalling in mechanosensing and intestinal barrier function *AP *JD Prof Anne Ridley / Dr Alexander Greenhough University of Bristol (apply through here) / University of the West of England Cell biology, Mechanosensing, Signalling, Omics, Bioinformatics