Biomolecular and Biophysical Studies

Encompasses most cellular and subcellular biology including microbiological systems and all aspects of gene function, protein structure, cytoskeleton & membrane systems and cellular transport. This theme also encompasses much of the synthetic biology area.

* These are SWBio DTP CASE studentships. As part of the programme, you will be required to undertake a placement with the CASE partner for a minimum of 3 months.

Project title Main / Rothamsted supervisor Host institution Keywords
A synthetic biology Bordetella vaccine Prof Nicholas Harmer University of Exeter (Streatham) Glycoscience; enzymology; structural biology; systems biology
Adaptive evolution of a yeast for palm oil replacement: genotype-phenotype relationships by nanopore sequencing * Dr Daniel Henk University of Bath DNA sequencing; epigenetics; evolution; fungi; genomics
ADDomer: Synthetic Multiepitope Virus-like Particle for Next-Generation Vaccines Prof Imre Berger University of Bristol Protein engineering; virus-like particles; recombinant vaccines; structural biology; infectious disease
Building a model of the Hypothalamic-Pituitary-Gonadal (HPG) axis Prof Krasimira Tsaneva-Atanasova University of Exeter (Streatham) Computational modelling; data driven biology; biological rhythms; information theory
Chronic effects of G protein-biased mu-opioid receptor agonists in the brain Dr Chris Bailey University of Bath Opioid, tolerance; neuroscience; GPCR; bias
Combining theory and experiment to explain the evolution of antibiotic resistance Dr James Spencer University of Bristol Enzymology; structural biology; computation; antibiotic resistance; evolution
Computational analysis of dynamic cell processes Prof David Stephens University of Bristol Microscopy; computational biology; bioimage analysis; cilia
Constructing catalytically proficient and functionally diverse enzymes from simple, de novo designed proteins Dr Ross Anderson University of Bristol De novo enzyme design; computational protein design; protein biophysics; oxidoreductases
Developing a novel bio-electronic device for automated stem cell expansion Dr Lucia Marucci University of Bristol Embryonic stem cells; biosensors; cell culturing platforms; control algorithms; personalised medicine
Developing better biopharmaceuticals using biomolecular simulation and modelling * Dr Christopher Pudney University of Bath T cell receptor; biomolecular simulation; molecular dynamics; biopharamceuticals
Developing plants as an expression system for mammalian ion channels Dr Mark Young Cardiff University Ion channel; protein expression; protein purification; cell signalling; arabidopsis
Development of bioimaging reporters to detect the delivery of biotherapeutics into multi-cellular systems Dr Peter Watson  Cardiff University Bioimaging; microscopy; cell biology; drug discovery; biotherapeutics
Effects of clustering and phosphorylation on nanoscale receptor signalling Prof Christian Soeller University of Exeter (Streatham) Biophysics; molecular biology; super-resolution; microscopy; mathematics heart
Enantioselective polyketide biocatalysis through simulation-led redesign Dr Marc van der Kamp University of Bristol Biomolecular simulation; enzymology; biosynthesis; structural biology
Endothelin signaling, enteric nervous system and Hirschsprung disease in zebrafish Prof Robert Kelsh University of Bath Developmental genetics; modelling human disease; zebrafish; agent-based modelling; hybrid modelling
Environmental bacteria as a reservoir of novel antibiotic resistance mechanisms Dr Susanne Gebhard  University of Bath Microbiology; antibiotic resistance; molecular biology; gene regulation; systems biology
Epigenetic regulation by D-type cyclins, a llink between cell division and development in plants? Dr Walter Dewitte Cardiff University Cell cycle; methylation; epigenetics; plant development; cytokinin
Gene expression regulation by RNA-binding proteins during fly development Dr Sonia Lopez de Quinto Cardiff University Gene expression regulation; RNA-binding proteins; RNP function; developmental biology; drosophila
Identifying signals guiding host traffic during immune responses Dr Mike Deeks University of Exeter (Streatham) Secretion; phytopathology; plant immunity; vesicle; mathematical modelling
Investigating cholesterol modulation of the mu-opioid receptor function using molecular pharmacology and computer modeling and simulation Prof Carmen Domene University of Bath Molecular pharmacology; opioid receptors; cholesterol; cell signalling; computer simulation
Investigating mitochondrial complex I assembly as a factor for disease Dr Vicki Gold  University of Exeter (Streatham) Mitochondria; respiration disease; electron; cryo-microscopy fluorescence microscopy
Local control of synaptic protein synthesis in neurons by microRNAs Dr Jonathan Hanley University of Bristol Neuroscience; cell biology; molecular biology; cell imaging; computational neuroscience
Magnetic field effects on plant biology: From cryptochromes to redox homeostasis Prof Nicholas Smirnoff University of Exeter (Streatham) Magnetic field effects; plant physiology; cryptochrome; oxidative stress response; quantum biology
Molecular analysis of the interaction of Bin pesticidal protein with its receptor Dr Colin Berry Cardiff University Protein toxins; protein engineering; protein structure
Molecular characterisation, modelling and prediction of organelle membrane dynamics in health and disease Prof Michael Schrader University of Exeter (Streatham) Molecular cell biology; biophysics; mathematic modelling; membrane dynamics; organelles
Nanopore RNA-Seq data analysis for characterising transcriptome malleability Dr Shobbir Hussain University of Bath Nanopore sequencing; Oxford Nanopore Technologies (ONT); transcriptomics; RNA splicing; epitranscriptome
Neurotrophic actions of botulinum toxin Prof Jeremy Henley University of Bristol Botulinum toxin; neuronal repair, neural stem cells, synthetic biology, synapse
Quantifying the evolution of antimicrobial resistance in mixed-species communities Prof Ivana Gudelj University of Exeter (Streatham) Antibiotic resistance; molecular mechanisms; mixed-species communities; evolution; mathematical modeling
Quantitative in vivo analysis of ligand-receptor interactions in the Wnt signalling network * Prof Steffen Scholpp University of Exeter (Streatham) Wnt signalling; ligand-receptor interactions; binding affinity; in vivo studies
RNA binding proteins and mRNA localisation in Drosophila spermatids Prof Helen White-Cooper  Cardiff University Drosophila; RNA; cell biology; differentiation; reproduction
Structure-function studies of the bacterial plasmid defence system Wadjet Prof Mark Szczelkun  University of Bristol Structural biology; biophysics; bacterial immune systems; single-molecule microscopy; electron microscopy
The life-cycle of IGF2 and its isoforms Prof Matthew Crump University of Bristol Structural biology; mass spectrometry; x-ray crystallography; hypoglycaemia; IGF2
The role of long non-coding RNA in signalling pathways regulating neural differentiation Dr Karim Malik University of Bristol LncRNA; neuronal differentiation; epigenetics; Wnt signalling
Ubiquitination studied by label-free real-time single molecule optical sensing Dr Stefan Bagby University of Bath Biochemistry; Biophysics; Nanophotonics; Post-translational modification; Ubiquitin ligase
Understanding the dynamics of human body weight change – mathematical modelling across age groups Prof Craig Williams University of Exeter (Streatham) Bioenergetics; dynamical systems; mathematics; physiology systems; biology
Understanding the impact of noise and ageing on antibiotic accumulation in gram-negative bacteria Dr Stefano Pagliara University of Exeter (Streatham) Biosciences; biophysics; microbiology; mathematical biology; microfluidics
Unlocking the therapeutic potential of E3 ubiquitin ligases through structure- function studies and Cryo-EM Dr Julien Licchesi University of Bath Structural biology; biophysics; E3 ubiquitin ligases; cryo-EM x-ray; crystallography
Unravelling how Histone Deacetylases (HDACs) regulate progenitor cell differentiation Dr Michael Taylor Cardiff University Cell differentiation; gene expression; genetics; confocal microscopy; progenitor cells
Unravelling the cellular mechanisms that provide specificity for insecticidal toxins against invertebrates and some cancer cells Dr Emyr Lloyd-Evans Cardiff University Insecticidal toxin; cell biology; protein structure; biochemistry; glycobiology
Virtual reality interactive multiuser molecular visualization and modelling for cryoelectron microscopy Prof Adrian Mulholland  University of Bristol Structural biology; molecular dynamics; protein structure; bimolecular structure