Advancing the frontiers of bioscience discovery

Promoting creative, curiosity-driven frontier bioscience to address fundamental questions in biology

*CASE: These are CASE DTP studentships. As part of the programme, you will be required to undertake a placement with the CASE partner for a minimum of 3 months.

*AP: These are Standard DTP studentships with an associate partner where you will be required to spend time with each of the partners. You will be asked to apply to one of the partners (as listed in the ‘Host Institution’ column), but this is just for administration purposes.  You will then be registered for your postgraduate studies at one of the partner universities of the lead supervisors.

 

PROJECT TITLE MAIN / ROTHAMSTED / LEAD SUPERVISOR HOST INSTITUTION KEYWORDS
A modular approach to the design and construction of protein-based, multi-centre redox and light harvesting chains Dr Ross Anderson University of Bristol De novo protein design, heme, electron transfer, computational design
A whole genome CRISPRi mitophagy screen for regulators of mitochondrial protein import quality control Dr Jon Lane University of Bristol Cell biology, biochemistry, CRISPRi, mitophagy, mitochondrial protein import
Activation of the plant cell cycle by sugars; pathways involved in stimulation of CYCD expression by carbohydrates Dr Walter Dewitte Cardiff University Forward genetic screen, CYCLIN D2, arabidopsis thaliana, next generation sequencing, sugar
Amyloid transcription block survival – Deriving functionally active peptide inhibitors of amyloidosis and toxicity Prof Jody Mason University of Bath Parkinson’s disease, amyloid, alpha-synuclein, protein-protein interactions, peptide inhibitors
Ancestral functions of genes regulated by imprinting in mammals Prof Andrew Ward University of Bath Developmental biology, epigenetics, evolution, growth, imprinting
Applying next generation structural biology methods to bacterial vaccine production Prof Nicholas Harmer University of Exeter (Streatham) Crystallography, structural biology, micro electron diffraction, polysaccharide, cryo-EM
Bioelectrical signatures of environmental sensing by microbial populations Dr Kirsty Y. Wan University of Exeter (Streatham) Motility, behaviour, biosensing, bioelectricity, algae
Biosensing using arrays of de novo designed proteins *CASE Prof Derek N Woolfson University of Bristol Biosensor, biotechnology, ultrafast fluorescence spectroscopy, peptide chemistry, peptide design and modelling
Building integrated bionanohybrid circuits by design: understanding and applying single protein molecule function Dr Dafydd Jones Cardiff University Synthetic biology, protein engineering, nanoscience, antimicrobial resistance, single molecule studies
Cerebellar control of cognition via higher-order thalamus Dr Paul Chadderton University of Bristol Neuroscience, cortex, cerebellum, thalamus, behaviour
Cholinergic modulation of spatial memory in cortical brain circuits Dr Jonathan Witton University of Exeter (Streatham) Neuromodulation, learning and memory, electrophysiology, imaging, optogenetics
Controlling chromosome conformation and content as a step towards synthetic cellular differentiation Dr Thomas Gorochowski University of Bristol Synthetic biology, nanopore sequencing, chromosome conformation, genome engineering, gene regulation
Coordination of the cortical code by gamma oscillations during learning Dr Joseph O’Neill Cardiff University Neuroscience, learning and memory,  optogenetics, sensory, cerebral cortex
Defining the role of membrane stability in the ability of Staphylococcus aureus to form part of the human microbiome Prof Ruth Massey University of Bristol Membrane stability, microbiome, staphylococcus aureus
Design of new fluorescent sensors for measuring heme in cells Prof Emma Raven University of Bristol Synthetic biology
Determining the conformational dynamics of the immune regulator STING and their control by STING ligands *CASE Dr Charlotte Dodson University of Bath Biophysics, chemical biology, protein dynamics, single molecule, innate immunity/cancer
Developing a new bio-imaging tool for correlative light electron microscopy Prof Paola Borri Cardiff University Bioimaging, biophysics, optical microscopy, electron microscopy, nanoparticles
Development of a platform for tracking  the stability of advanced BioTherapeutics *AP Dr Christopher Pudney / Prof Steve Conlan University of Bath (apply here) / Swansea University Biophamaceuticals, antibodies, exosomes, biophysics, fluorescence
Development of peptide-based delivery systems to improve biotherapeutic efficacy within multicellular tumour models Dr Peter Watson Cardiff University Bioimaging, microscopy, cell biology, drug discovery, biotherapeutics
Development, function and evolution of the mammalian jaw joint and middle ear Prof Emily Rayfield University of Bristol Evolution, development, mammals, biomechanics, function
Elucidating the genetic and biochemical architecture underpinning cross-kingdom interactions Dr Stephanie Diezmann University of Bristol Microbiology, microbial communication, whole genome sequencing, genome-scale competition assays, mode-of-action analyses
Endothelin signaling and neural crest development in zebrafish Prof Robert Kelsh University of Bath Endothelin, endothelin receptor, neural crests, pigment cells, peripheral nervous system
Engineering biosynthetic pathways and biocatalysts to deliver new antimicrobial compounds Prof Chris Willis University of Bristol Biocatalysts, natural products, spectroscopy, synthesis, synthetic biology
Establishing evolutionary timescales Prof Philip Donoghue University of Bristol Molecular clock, timescale, evolution, calibration, phylogeny
Genomic and transcriptional mechanisms underpinning temperature homeostasis and pathogenicity in two amphibian-killing chytrid fungi Dr Rhys Farrer University of Exeter (Streatham) Bioinformatics, genomics, mycology, chytrids, evolution
High resolution imaging of extracellular matrix formation Prof David Stephens University of Bristol Extracellular matrix, high resolution microscopy, cell biology, membrane trafficking, atomic force microscopy
Individual differences in learning and behaviour: Computational models and in vivo experimentation Prof Rob Honey Cardiff University Affect, cognition, behaviour, computational models
Mechanisms of electroreception in bumblebees and honeybees Prof Daniel Robert University of Bristol Neuroethology, sensory biophysics, insect behaviour, plant-pollinator interactions
Mechanisms of molecular recognition by the prokaryotic argonautes Prof Mark Szczelkun University of Bristol Argonautes, prokaryotic defence systems, genome engineering, biophysics, single-molecule microscopy
Memories of touch: The role of higher order cortical areas in processing and remembering tactile textures Prof Kevin Fox Cardiff University Neuroscience, learning and memory, DREADDs, sensory, cerebral cortex
Merging maths and biology to understand how the dynamics of dentate gyrus circuitry supports memory formation in hippocampus Prof Zafar Bashir University of Bristol Pattern separation, memory, electrophysiology, hippocampus, computational neuroscience
Modelling the effect of ageing in silico and on Drosophila and mouse clock neurons Dr James Hodge University of Bristol Drosophila, electrophysiology, computational modelling, circadian rhythms, ageing
Molecular characterisation, modelling and prediction of organelle membrane dynamics in health and disease Prof Michael Schrader University of Exeter (Streatham) Molecular cell biology, biophysics, mathematic modelling, membrane dynamics, organelles
Phosphoregulation of argonaute function in synaptic plasticity and memory Prof Jonathan Hanley University of Bristol Neuroscience, memory, microRNA, synaptic plasticity, translation
Phylogeny-guided (meta) genome mining for the discovery of antimicrobial natural products from marine bacteria Dr Patricia Sanchez-Baracaldo  University of Bristol Phylogenetics, microbiology, genomics, bioinformatics, marine biology, natural products, biosynthesis
Physiological capacity of hibernating bats and implications for immunity and viral load Dr Orly Razgour University of Exeter (Streatham) Animal physiology, immunology, virology, bat, hibernation
Predicting the outcome of coinfection using a model of TB in mice Dr Joanne Lello Cardiff University Coinfection, immune response, One Health,TB, pathogens
Rational design of phage-antibiotic therapies as the new frontier for tackling antibiotic resistance Dr Stefano Pagliara University of Exeter (Streatham) Microbiology, phage biology, biophysics, antimicrobial resistance, systems biology
Seaweed diseases: understanding seaweed host-pathogen interactions to improve commercial seaweed production *AP Dr Michiel Vos / Dr Ruth Airs University of Exeter (Penryn) (apply here) / Plymouth Marine Laboratory Infection ecology, bioinformatics, metabolomics, microbiology, chemical ecology
Simulation-led investigation and engineering of enzymes involved in abyssomicin antibiotic biosynthesis Dr Marc van der Kamp University of Bristol Structural biology, biomolecular simulation, enzymology, biosynthesis, synthetic biology
Single molecule dynamics of enzyme catalysis for thermoadaptation and design Prof Adrian Mulholland University of Bristol Enzymology, protein dynamics, simulation, biophysics
Spatial and temporal resolution of the cellular (oxy) lipidome and its relation to inflammatory cell function *AP Prof Andrew Crosby / Prof Helen Griffiths University of Exeter (St Luke’s) (apply here) / Swansea University Genetics, biochemistry, lipid metabolism, mitochondria immunology
Structure: Function correlation in CtIP: a key DNA repair factor implicated in human disease Prof Mark Dillingham University of Bristol DNA repair, genetic instability, cancer, biochemistry, cell biology
The biology and biotechnological potential of marine fungi bioprocessing *AP Dr Mike Allen / Dr Michael Cunliffe University of Exeter (Streatham) (apply here) / Marine Biological Association Fungi, biology, biotechnology, bioprocessing, enzymes
The cardiac dyad signalling proteome and its modulation during cardiac protection Prof Christian Soeller University of Exeter (Streatham) Heart, protein-protein interactions, super-resolution microscopy, mass spectrometry, proteomics
The impact of change in the environment and the ability to deal with it on an individual’s affective state and welfare Prof Michael Mendl University of Bristol Animal welfare, affective state, learning,  prediction error, individual differences
The interplay between microbes and host in the development of the zebra fish enteric nervous system Dr Andrew Preston University of Bath Microbiome, zebra fish, development, bioinformatics, cell biology
The landscape of a parasite surface: Characterisation of the exposed invariant epitopes on the surface of African trypanosomes as putative targets of novel immunotherapeutics *CASE Dr Paula MacGregor University of Bristol Trypanosomes, parasitology, molecular biology, molecular modelling, peptides
The mechanisms and evolution of senescence in microbes Dr Andrew Young University of Exeter (Penryn) Biology, evolution, ageing, mathematics, microbiology
The nature of modularity in polyketide synthases: a computational design approach to understand and engineer biological assembly lines Prof Matthew Crump University of Bristol Polyketide synthase, NMR spectroscopy, protein design, chemical biology, protein biochemistry
The role of bacterial immune systems in the spread of antimicrobial resistance Prof Edze Westra University of Exeter (Penryn) Bacteria, CRISPR-Cas, restriction-modification, antimicrobial resistance, antibiotics
The role of VTA GABA neurons in reward learning Dr Paul Dodson University of Bristol Dopamine, reward, GABA, computational modelling, neuroscience
The roles of YAP/TAZ-WBP2 interplay in epidermal tissue repair Dr Gernot Walko University of Bath Cell biology, molecular biology, systems biology, transcriptional regulation, stem cells
Visual-spatial processing within the retrosplenial cortex Prof Seralynne Vann Cardiff University Neuroscience, brain imaging, behaviour, neural circuits, memory
What are they talking about?  A study investigating the meanings behind ultrasonic vocalisations Prof Emma Robinson University of Bristol Animal emotion, welfare, affective biases, machine learning, DeepSqueak
Windows of opportunity: epigenetic sensitive windows spanning generations Dr Bram Kuijper University of Exeter (Penryn) Epigenetics, Development, DNA methylation, Developmental origins of health, Paternal effects