Advancing the frontiers of bioscience discovery

Promoting creative, curiosity-driven frontier bioscience to address fundamental questions in biology

*CASE: These are CASE DTP studentships. As part of the programme, you will be required to undertake a placement with the CASE partner for a minimum of 3 months.
*AP: These are Standard DTP studentships with an associate partner where you will be required to spend approximately a total of 50% of your time with each of the partners.

Project title Main / Rothamsted supervisor Host institution Keywords
Activation of the plant cell cycle by sugars; pathways involved in stimulation of CYCD expression by carbohydrates Dr Walter Dewitte Cardiff University Forward genetic screen, CYCLIN D2, Arabidopsis thaliana, next generation sequencing
ADDomer: Synthetic multiepitope virus-like particle for next-Generation vaccines Prof Imre Berger University of Bristol Infectious disease, next-generation vaccines, synthetic biology, cryo-electron microscopy, bench-to-bedside
Advancing homology-directed repair driven CRISPR technologies in zebrafish Dr Rebecca Richardson University of Bristol CRISPR, zebrafish, genome editing, technology development, in vivo
Amyloid transcription block survival – Deriving functionally active peptide inhibitors of amyloidosis and toxicity Prof Jody Mason University of Bath Parkinson’s disease, amyloid, alpha-synuclein, protein-protein interactions, peptide inhibitors
An exploration of the links between mitochondrial function and splicing regulation Prof Lorna Harries University of Exeter (Streatham) Mitochondria, alternative splicing, molecular genetics, bioinformatics
Analysis of gene interactions in neurodegeneration Dr Michael Taylor Cardiff University Neuroscience, gene function, molecular genetics, cell death, cell differentiation
Ancestral functions of genes regulated by imprinting in mammals Prof Andrew Ward University of Bath Developmental biology, epigenetics, evolution, growth, imprinting
Automated T-cell expansion in an integrated bioelectronics microfluidic chip: paving the way for personalised T-cell therapies for blood cancer Dr Mirella Di Lorenzo University of Bath Biosciences, personalised therapeutics, mathematical biology, microfluidics, control algorithms
Combining theory and experiment to explain the evolution of antibiotic resistance Dr James Spencer University of Bristol Antibiotic resistance, structural biology, computational chemistry, enzymes
Constrained evolution – possibilities and impediments in pigment patterning Prof Robert Kelsh University of Bath Evolution, pattern formation, zebrafish, mathematical modelling, pigmentation
Correlation of imaging and impedimetric data to predict cell state and changes in bioreactors *AP Prof Paul Verkade / Prof Richard Luxton University of Bristol (apply here) / University of the West of England; UWE Bioimaging, optical microscopy, sensing, Correlative Imaging, Impedance spectroscopy
Developing a new bio-imaging method based on correlative light electron microscopy with gold nanoparticles Prof Paola Borri Cardiff University Bioimaging, biophysics, optical microscopy, electron microscopy, nanoparticles
Developing and applying methods of molecular clock calibration to date then assembly of metabolisms and the deep species divergences in the tree of life Prof Philip Donoghue University of Bristol Evolution, metabolisms, phylogeny, molecular clock, genome, tree of life
Development of peptide-based delivery systems to improve biotherapeutic efficacy within tumour models Dr Peter Watson Cardiff University Bioimaging, microscopy, cell biology, drug discovery, biotherapeutics
Dissecting the function of Wnt signalling in zebrafish neural crest development Prof Steffen Scholpp University of Exeter (Streatham) Cell biology, genetics, high-resolution imaging, in vivo
Effects of clustering and phosphorylation on nanoscale receptor signalling Prof Christian Soeller University of Exeter (Streatham) Biophysics, molecular biology, super-resolution, microscopy, mathematics, heart
Enzyme mechanisms studied by single molecule optical sensing Prof Frank Vollmer University of Exeter (Streatham) Biochemistry, biophysics, nanophotonics, post-translational modification, ubiquitin ligase
Epigenetic Interplay: How Maternal and Paternal Effects Interact in Australian Crickets Dr Bram Kuijper University of Exeter (Penryn) Epigenetics, mathematical modeling, gene expression, gene regulatory network, systems biology
Evaluating the contribution of transposons to agricultural domestication Dr Alex Hayward University of Exeter (Penryn) Genomics, domestication, transposon, agriculture, bioinformatics
Extremophilic enzymes: investigating structural adaptation through rapid physics-based geometric simulation Prof Alison Walker University of Bath Biophysics, Structural biology, biomolecular simulation, enzyme, software development
Functional roles of cholinergic signalling in the retrosplenial cortex Dr Jonathan Witton University of Exeter (Streatham) Acetylcholine, neuromodulation, learning and memory, electrophysiology, imaging
Horizontal transfer of antiviral defences between bacterial species Dr Tiffany Taylor University of Bath Evolution, CRISPR, antimicrobial resistance, bacteria, phage
Investigating conserved long non-coding RNA functions during melanocyte development in zebrafish and human melanoma Dr Keith Vance University of Bath Long non-coding RNA, melanocyte, CRISPR, gene regulation, stem cells
Investigating how imprinted Grb10 influences brain growth Prof Anthony Isles Cardiff University Epigenetics, systems neuroscience, functional genomics, bioinformatics, neuroimaging
Investigating how novel long non-coding RNAs modulate signalling pathways and neuronal cell fate Dr Karim Malik University of Bristol Cell-fate, epigenetics, lncRNA, neuronal, differentiation
Investigating the Post-Antibiotic Effect at a single-cell resolution Dr Tobias Bergmiller University of Exeter (Streatham) Antibiotic resistance, microbiology, microfluidics, single cell
Local control of synaptic protein synthesis in neurons by microRNAs Prof Jonathan Hanley University of Bristol Neuroscience, cell biology, molecular biology, cell imaging, computational neuroscience
Mathematical modelling of actin in animals and plants Dr David Richards University of Exeter (Streatham) Cytoskeleton, actin, cross-kingdom biology, mathematical modelling, Image analysis
New probes to elucidate and capitalize on nature’s biosynthetic machinery Prof Chris Willis University of Bristol Antibiotics, biocatalysts, isotopes, molecular biology, polyketides
Pollen-pistil communication in flowering plants: a role for pollen endocytosis? Dr Barend H. J. de Graaf Cardiff University Plant reproduction, pollen, signalling, endocytosis, membrane trafficking
Precision genome editing using modulators of dsDNA break repair pathways Prof Christiane Berger-Schaffitzel University of Bristol CRISPR/Cas9, DNA Repair, ribosome Display, nanobodies, TRIM-Away
Re-engineering the building blocks of bacterial natural product assembly lines Prof Matthew Crump University of Bristol Antibiotics, anti-MRSA, kalimantacin, structural biology, Cryo EM
Regulation of membrane contact sites in mammalian cells Dr Joseph Costello University of Exeter (Streatham) Molecular cell biology, mammalian cells, organelles, membrane contact sites
Regulation of neuronal energy production by SUMOylation *AP Prof Jeremy Henley / Dr Tim Craig University of Bristol (apply here) / University of the West of England; UWE Neurones, SUMOylation, metabolism, mitochondria, bioenergetics
Regulation of stem cell biology by RNA-binding proteins during fly development Dr Sonia Lopez de Quinto Cardiff University Stem cell biology, gene expression regulation, RNA-binding proteins, developmental biology, Drosophila
RNA binding proteins and mRNA localisation in Drosophila Prof Helen White-Cooper Cardiff University RNA localisation, reproduction, developmental biology, imaging, Drosophila
Role of microRNAs in regulating sex differences in stress responsive neurocircuitry across the lifespan Prof Mark Lindsay University of Bath Bioinformatics, neuroscience, molecular biology, neurobiology
Simulation-led redesign to generate enantioselective biocatalysts Dr Marc van der Kamp University of Bristol Structural biology, biomolecular simulation, enzymology, biosynthesis, synthetic biology
Single-molecule analysis of the CRISPR-associated transposons (CAST) Prof Mark Szcelkun University of Bristol Genome engineering, biophysics, CRISPR, transposons, single-molecule microscopy
Structural analysis of the inter-membrane bacterial secretosome Prof Ian Collinson University of Bristol Bacterial secretion, Membrane biogenesis, Biochemistry, Cryo-EM, Antibiotic targeting
Taking de novo protein design and assembly into bacterial cells Prof Dek Woolfson University of Bristol de novo protein design, E. coli, imaging, proteome, synthetic biology
The impact of change and the ability to deal with it on an individual’s affective state and welfare Prof Mike Mendl University of Bristol Animal welfare, affective state, learning, prediction error, individual differences
The role of VTA GABA neurons in reward learning Dr Paul Dodson University of Bristol Dopamine, Reward, GABA, computational modelling, neuroscience
To fight or to flourish: Do plants decide in the heat of the moment? Understanding the coordination of growth and immunity Dr Vinod Kumar University of Exeter (Streatham) Climate resilience, environmental signalling, temperature sensing, disease resistance
Understanding how interneurons in medial prefrontal cortex control associative recognition memory Prof Zafar Bashir University of Bristol Learning and memory, prefrontal cortex, inhibitory interneurons, cortical circuits, dementia
Unravelling the function of the unusual antioxidant ergothioneine in plants and photosynthetic protists Prof Nicholas Smirnoff University of Exeter (Streatham) Algal biology, plant metabolism, metabolomics, reactive oxygen species, Antioxidants