University of the West of England (UWE) profiles

Intake 2020

Sioned Heal

Standard studentship with associate partner: In collaboration with Bristol + University of the West of England (UWE) 

Sioned graduated from the University of Bristol in 2020 with an Msci in Biochemistry. Her final year project was spent in Jeremy Henley’s lab studying the role of sentrin specific proteases (SENPs) in regulating the SUMOylation status of known SUMO targets, specifically the Rho GDP-dissociation inhibitor (RhoGDI).

Sioned will continue pursuing this area of interest by undergoing a PhD project in Bristol under the supervision of Prof Jeremy Henley focusing on the regulation of neuronal energy production by SUMOylation. Here, the SUMOylation status of mitochondrial proteins will be studied and associated with changes in neuronal metabolism. Part of the project will be undertaken in UWE under the supervision of Dr Tim Craig, where the Seahorse XFe24 will be used to measure key metabolic parameters and determine how changes in protein SUMOylation may affect metabolism.

LinkedIn profile

Celia Mellor

Standard studentship with associate partner: In collaboration with University of the West of England (UWE) + Bristol 

Celia graduated from the University of Bristol in 2020 with a BSc in Biochemistry. Using molecular dynamics, docking and in vitro techniques her final year project investigated potential inhibitors of P. falciparum’s lactate dehydrogenase in the lab of Dr Richard Sessions. This experience, along with a summer studentship with Dr Mike Jones, attempting to covalently link phycocyanin to purple bacteria reaction centres to develop biophotovoltaics, confirmed her keen interest in molecular biology.

Technology plays a vital role in aiding scientific discovery and Celia’s PhD project will use correlative microscopy and impedance spectroscopy to study changes in cell physiology for the use in bioreactors. The project is supervised by Professors Richard Luxton and Paul Verkade in a joint venture between UWE and the University of Bristol.