Improving animal and human health and wellbeing across the lifecourse.

*CASE: These are CASE DTP studentships. As part of the programme, you will be required to undertake a placement with the CASE partner for a minimum of 3 months.

*AP: These are Standard DTP studentships with an associate partner where you will be required to spend time with each of the partners. You will be asked to apply to one of the partners (as listed in the ‘Host Institution’ column), but this is just for administration purposes.  You will then be registered for your postgraduate studies at one of the partner universities of the lead supervisors.  Your registered university will be confirmed by the DTP following the interview stage of the selection process.

*JD: This project in collaboration with the University of Bristol and the University of the West of England (UWE) is subject to a joint degree award. Successful applicants will be registered at both these institutions, and graduates will be awarded a joint degree from these two institutions upon successful completion of the PhD programme.

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PROJECT TITLE	MAIN / ROTHAMSTED	HOST INSTITUTION	KEYWORDS
A Covalent Phage Display Approach for the Discovery of Lipoteichoic Acid Synthase Inhibitors	Dr Scott Lovell	University of Bath	Covalent Drug Discovery, Peptide Phage Display, Antibiotic Resistance, Structural Biology, Chemical Proteomics
Ageing and body clock rhythms: The importance of a social network	Prof Hugh Piggins	University of Bristol	socializing, sex differences, sleep, cognition, mouse
Aging before birth: identifying influences of modifiable maternal lifestyle on telomere length	Prof Rosalind John	Cardiff University	Healthy aging, Maternal diet and nutrition, Telomeres, Human stem cells, Intervention
Applying integrative microbiomics to understand the health threats of environmental microbiomes	Dr Anne Leonard	University of Exeter (Penryn)	Bioinformatics, Integrative microbiomics, Antimicrobial resistance, Microbiology, Ecology
Autophagy and the integrated stress response in neurodegeneration: how endomembrane trafficking shapes human neuronal/glial interactions during stress	Prof Jon Lane	University of Bristol	Autophagy, endocytosis, neurons, glia, iPSCs.
Does sex really matter? Quantifying the importance of sex-disaggregated analysis for improving experimental reproducibility in an experimental fish model *CASE	Dr Robert Ellis	University of Exeter (Streatham/St Luke’s)	Ecotoxicology, Physiology, Animal Husbandry, Sex-disaggregation, Host-pathogen interaction
Joint function throughout the life course	Prof Emily Rayfield	University of Bristol	Zebrafish, Skeleton, loading, genes, ageing
Mechanism of free fatty acid protection against SARS-CoV2 viral replication	Prof Paul Verkade	University of Bristol	SARS-CoV2, Free fatty acids, cryo electron tomography, correlative light electron microscopy, membrane remodelling
Non-genetic paternal effects on offspring reproduction and health: mechanisms and evolutionary consequences in a bird model system	Dr Barbara Tschirren	University of Exeter (Penryn)	Developmental Origins of Health, Epigenetics, Reproductive Health and Behaviour, Fertility and Sustainable Animal Breeding, Mechanisms of Evolutionary Change
The impact of meal-feeding on human mental and metabolic health	Prof James Betts	University of Bath	Feeding patterns, Mental health, Metabolic health, Hypothalamo-pituitary-adrenal axis, Human volunteers
The making of a pathogen: the interaction between virulence- and antibiotic resistance evolution	Dr Michiel Vos	University of Exeter (Penryn)	antimicrobial resistance, virulence, genomics, experimental evolution, opportunistic pathogens
Understanding cellular interactions in a 3D bioprinted model of the glomerulus	Dr James Armstrong	University of Bristol	Kidney, cell biology, bioprinting, biomaterials, tissue engineering
Understanding receptor-mediated mechanosensing and signalling in cell barrier function during tissue homeostasis and stress responses *AP *JD	Prof Anne Ridley / Dr Alexander Greenhough	University of Bristol (apply through here) / University of the West of England	Cell biology, Mechanosensing, Signalling, Omics, Bioinformatics
Understanding the cellular processes that support pattern separation in the hippocampal dentate gyrus and how ageing affects our memory	Dr Denize Atan	University of Bristol	Ageing, Pattern separation, Dentate gyrus, Memory, Computational modelling
Understanding the genetic basis of reproductive strategy in a parasitic nematode system	Dr Vicky Hunt	University of Bath	Reproduction, Parasites, Genetics, small RNA, Nematodes
Understanding the role of ketone bodies in the regulation of erythropoietin production	Dr Javier Gonzalez	University of Bath	Human Physiology, Cell Signalling, Metabolism, Renal Physiology
U-RHYTHM: developing a novel technology for the investigation of tissue-level thyroid and sex hormone dynamics in humans	Prof Stafford Lightman	University of Bristol	Biorhythms, Automated sampling, Hormone:plastic interfaces, Sex hormones, Thyroid hormone